Nothing to Whine About in Montepulciano (video) CheapOair Staff February 22, 2012 Videos Between the popular tourist cities of Rome and Florence is Tuscany’s Montepulciano. The Medieval and Renaissance town, famous for its wine made from Montepulciano grapes, offers cathedrals, squares and stunning natural landscapes for those wanting to head off the beaten path on their way from popular tourists sites like the Colosseum in Rome to the Uffizi Gallery in Florence. Don’t forget to follow us on Twitter for exclusive travel deals!