AirTran Airways Labeled Safest Airline in US CheapOair Staff January 28, 2011 general AirTran has earned the nod of safest airline in the U.S. based on a report put together by USNews.com. AirTran Airways reported the least amount of incidents in 2010. The airline took 255,500 flights in 2010 and only had a handful of incidents. The top five safest airlines according to the report went like this: 1. AirTran 2. Southwest Airlines 3. US Airways 4. Continental Airlines 5. Delta Airlines Source: CFNews13