Lufthansa Will be First to Fly A380 to Miami CheapOair Staff March 31, 2011 general Miami to be Sixth Route for the Lufthansa A380 Lufthansa announced Thursday that they’ll be flying the A380 to Miami beginning on June 10th. The A380 will be replacing the B747 on the Frankfurt-Miami route. It will be the sixth route for jet, and the third U.S. The German carrier will be the first to operate the A380 to Miami. Source: Business Traveller